Abstract
Mass spectrometry (MS) is a powerful tool for analyzing complex mixtures such as natural organic matter (NOM), humic substances (HS), and petroleum. MS disperses and resolves analyte ions with far greater peak capacity than any chromatographic technique. Unfortunately, even the highest-resolution MS cannot separate isomers. Therefore, tandem chromatography and MS techniques must be developed that combine isomeric separation with detailed compositional characterization. To develop such techniques, a means of identifying isomeric separation is requisite. Hydrogen/deuterium exchange (HDX) is an attractive means to distinguish isomers because the ability to exchange hydrogen(s) depends critically on structure. Here, both solution H/D exchange and ion-molecule reaction (IMR) H/D exchange were investigated. We present the first IMR results for fully resolved NOM isobars and the first direct evidence of isomeric separation of NOM through reversed-phase chromatography.
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