Abstract
Over the past decade ion mobility (IM) coupled with mass spectrometry (MS) has emerged as a wide spread analytical technique, utilized in research areas ranging from small molecule to proteins analyzed under native-MS and solution conditions. The ion-neutral collision cross section (Ω) derived from an IM experiment can be used to make inferences about the ion's size, shape and charge distribution, when compared to molecular dynamic (MD) or quantum mechanically (QM) derived candidate structures. IM can also be used as an orthogonal separation technique when coupled with liquid chromatographic (LC) separations. IM has been readily adopted by academic research groups and has been demonstrated to be highly enabling, resulting in the inception of completely new research areas, such as gas-phase structural biology. The same cannot be said for IM in pharma, where it is still perceived as a standalone, research-only based analytical tool. Herein, we will describe key innovations of IM instrumentation by current MS vendors and IMs application within academic and pharmaceutical research and how these developments have been, and can be applied to research discovery efforts within the pharmaceutical industry.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.