Abstract
THE PURPOSE of this paper is to report our experiences in the use of ion-exchange resins in the treatment of high intestinal fistulae and the results of some experimental work on the antitryptic activity of these substances. Because polyamine-formaldehyde anion-exchange resins have been reported to have an inhibitory effect on tryptic enzyme activity, 1 it occurred to us that these resins might be of use in reducing the cutaneous excoriation accompanying gastric, duodenal, and high jejunal fistulae. INTRODUCTION In 1945 Segal 2 first suggested the use of anion-exchange resins in the treatment of peptic ulcer. He found that these substances reduced gastric acidity by absorbing free hydrochloric acid and mitigating the activity of the tryptic enzymes of the stomach by altering the pH of the medium. Martin and Wilkinson 1 later found that anion-exchange resins deactivated 80% of the gastric pepsin when they were mixed with a solution of gastric
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