ION EXCHANGE RESINS: AN APPROACH TOWARDS TASTE MASKING OF BITTER DRUGS AND SUSTAINED RELEASE FORMULATIONS WITH THEIR PATENTS

Abstract

The purpose of this review is to cover various aspects related with the use of ion exchange resins for taste masking of bitte r drugs and for formulating sustained release dosage form. Ion exchange resins are wate r insoluble cross - linked polymers containing a salt - forming group at repeating positions on the polymer chain and have the ability to exchange counter - ions within aqueous solutions surrounding them. The bitterness of pharmaceutical medicines plays a critic al role in patient compliance, as the oral administration of bitter drugs is often hampered by their unpleasant taste which l eads to non - compliance and further worsening of diseased condition. One of the popular approaches in the taste masking of bitter dr ugs is based on IER. For taste masking purpose weak cation exchange or weak anion exchange resins are used, depending on the nature of drug. The drug resin complex is absolutely tasteless with no after taste, and at the same time, its bioavailability is no t affected. Sustained release dosage forms are designed to release a drug at a pre determined rate in order to maintain a constant drug concentration for a specific period of time with minimum side effects . The usage of IER during the development of sustai ned release formulations plays a significant role because of their drug retarding properties. In this review also incorporates various pa tents related to taste masking and sustained release formulations using IER.