Abstract
An IC/MS method was developed using thermospray and electrospray interfaces to obtain the mass spectra of ionic compounds in agricultural chemicals. This is an easy, rugged, and sensitive method and offers several advantages over the conventional HPLC/MS with ion-pairing reagents for the analysis of highly polar compounds. Ion exchange chromatography was used to separate the ionic compounds from other components in the sample. Sodium hydroxide mixed with methanol and water was used as the eluent. To make the eluent containing sodium hydroxide compatible with MS, an on-line solid-phase chemical suppressor was used, which removed sodium ions from the mobile solvent before it entered the mass spectrometer. The suppressor is easy to use, is rugged, and can withstand the high back-pressure generated by the thermospray LC/MS interface. It also works well with the electrospray interface.
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