Abstract
EDITORIAL article Front. Pharmacol., 07 May 2012Sec. Pharmacology of Ion Channels and Channelopathies Volume 3 - 2012 | https://doi.org/10.3389/fphar.2012.00086
Highlights
Patch-clamp is the gold standard technique to record ion channel activity (Hamill et al, 1981)
The development of other important features such as temperature control, the ability to record action potentials, and the testing of drugs on more relevant physiological models improve the quality of results
These automated patch-clamp (APC) systems, can only be used with suspended cell lines transfected with the ion channels to be studied, thereby not allowing for the study of the processes involved in synaptic communication
Summary
Patch-clamp is the gold standard technique to record ion channel activity (Hamill et al, 1981). These methods, need improvements with respect to throughput, quality of the electrophysiological recordings and the physiological cellular models used for drugs and safety testing.
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