Abstract
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease (COVID-19), has been classified by the World Health Organization (WHO) as an ongoing pandemic. Owing to the global emergency, there is an unmet need to identify effective and scalable therapeutic options to attenuate the early stages of virus infection. SARS-CoV-2 has different stages of the infection cycle. The first phase is characterized by infection and replication of the virus within the host cells. The last phase occurs with cytokine storm leading to cellular apoptosis [1]. We posit the rationale for ion channel inhibition as a novel therapeutic target to counteract SARS-CoV-2 infection and replication. Within this framework, we discuss the potential clinical role of the ion channel inhibitors amiodarone and verapamil against COVID-19 that deserves clinical investigations.
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