Abstract
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease (COVID-19), has been classified by the World Health Organization (WHO) as an ongoing pandemic. Owing to the global emergency, there is an unmet need to identify effective and scalable therapeutic options to attenuate the early stages of virus infection. SARS-CoV-2 has different stages of the infection cycle. The first phase is characterized by infection and replication of the virus within the host cells. The last phase occurs with cytokine storm leading to cellular apoptosis [1]. We posit the rationale for ion channel inhibition as a novel therapeutic target to counteract SARS-CoV-2 infection and replication. Within this framework, we discuss the potential clinical role of the ion channel inhibitors amiodarone and verapamil against COVID-19 that deserves clinical investigations.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.