Abstract
The Na+/H+ exchangers (NHE) are a family of proteins that regulate intracellular pH, sodium levels and cell volume, and contribute to the control of the cell cycle, cell proliferation, cell migration and vesicle trafficking. However, despite their physiological importance, detailed molecular-level structural information for the NHE has been lacking. Although a number of prokaryotic structures of sodium/proton antiporters are known, it is not clear in how far the insights from these structures are applicable to the medically important mammalian homologs.
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