Abstract

Ascorbic acid is a water-soluble vitamin provided with strong antioxidant action, that fulfills an important immune protective role of the body against infections and prevents various cancers appearance. The main goal of this study was to exactly quantify pure ascorbic acid in tablets of two pharmaceuticals. Proposed objective consisted in improvement and application of a iodometric titration method in ascorbic acid quantitative analysis. Ascorbic acid content per tablet in both studied pharmaceuticals was 173.84 mg, very close to official stated amount of active substance (180 mg). Allowed percentage deviation from declared content of pure ascorbic acid was only 3.42 %, below maximum value of � 5 % imposed by Romanian Pharmacopoeia 10-th Edition, according to European and International standards. Statistical analysis confirmed experimental obtained results and revealed low Standard Error value SE = 0.214476, which has fallen within normal limits. Confidence Level value (95.0 %) = 0.551328 and Standard Deviation SD = 0.525357. were within normal range of values. Relative Standard Deviation (Coefficient of variation or homogeneity) RSD = 26.268% was found below maximum range of accepted values (30-35%). P value = 7.44. 10-6 was located within normal limits, P [ 0.001, so the experimental obtained results has shown highest statistical significance. Thus, studied titration method can be successfully used in quantitative analysis of ascorbic acid from different samples.

Highlights

  • Ascorbic acid is a water-soluble vitamin provided with strong antioxidant action, that fulfills an important immune protective role of the body against infections and prevents various cancers appearance

  • Vitamin C is a water-soluble compound with powerful antioxidant action that fulfills a significant immune protective role of the body against infections and various diseases

  • Ascorbate supplementation in cancer patients, either enhances the antitumor effects of chemotherapy or reduces its toxicity [1,2,3,4]. This vitamin possesses powerful antioxidant action by making a redox oxidation-reduction system in the cells, which contributes to the non-enzymatic transport of hydrogen to the tissues

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Summary

Introduction

Ascorbic acid is a water-soluble vitamin provided with strong antioxidant action, that fulfills an important immune protective role of the body against infections and prevents various cancers appearance. Vitamin C is a water-soluble compound with powerful antioxidant action that fulfills a significant immune protective role of the body against infections and various diseases It increases general immunity of the human body and prevents different cancers appearance. Ascorbate supplementation in cancer patients, either enhances the antitumor effects of chemotherapy or reduces its toxicity [1,2,3,4] This vitamin possesses powerful antioxidant action by making a redox oxidation-reduction system in the cells, which contributes to the non-enzymatic transport of hydrogen to the tissues. Patients with unbalanced hyperglycemia and diabetes have low levels of vitamin C in the cell, which causes increased oxidative stress with high risk of atherosclerosis This vitamin is brought to the body exclusively by food intake, especially by daily consumption of fresh fruits and vegetables [1,2,3,4,5]

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