Abstract
Objective To explore the relationship between iodine-rich diet and thyroid cancer. Methods PubMed, Excerpt Medica Database (EMbase), China National Knowledge Infrastructure (CNKI), WanFang, WeiPu, and China Biology Medicine disc (CBM) were searched through computer, for relevant articles published before June 2016, to find case-control studies concerning the relationship between iodine-rich diet and thyroid cancer. According to the inclusion and exclusion criteria for data extraction and quality evaluation, Meta-analysis was performed using Stata 12.0. Results Totally 19 case-control studies were included in this study. Cases and controls were 47 316 people (case 6 662, control 40 654). The quality of the literature was reliable (the score was 6 points and more). Meta analysis results showed a total of 13 articles studied fish, more frequent intake (3 times per week and more) of fish can reduce the risk of thyroid cancer [odds ratio (OR)= 0.87, 95% confidence interval (CI): 0.77-0.98, P 0.05), saltwater fish (OR= 0.94, 95%CI: 0.50-1.77,P > 0.05) and freshwater fish (OR= 0.90, 95%CI: 0.66-1.21, P > 0.05) had no effect on the prevalence of thyroid cancer. Conclusion Seafood, marine animal foods and seaweed will increase the risk of thyroid cancer. Key words: Thyroid neoplasms; Risk factors; Case-control study; Meta-analysis
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