Abstract
Alkyl aryl ketones are converted into the corresponding α-sulfonyloxyketones, in moderate to excellent yields, via a novel procedure that utilizes Oxone®, p-toluenesulfonic acid or methanesulfonic acid and molecular iodine in a mixture of acetonitrile and 2,2,2-trifluoroethanol. The yield is found to be dependent on the nature of the ketone. A mechanism is proposed in which the key intermediates are an α-iodoketone and a subsequently formed α-iodosylketone. The latter reacts with the sulfonic acid to afford the α-sulfonyloxyketone product.
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