Abstract
Iodine-mediated highly convenient strategy for the C-3 arylation of indoles with p-quinols is presented. The present work surpasses in forming a C–C bond at the meta-position of the phenols, which is traditionally challenging to functionalize. This protocol further leads the way to have ascendable, forthright access to phenol-assimilated heterocycles which have powerful applications both in synthetic and medicinal chemistry. Iodine-mediated highly convenient and rapid protocol for C-3 arylation of indoles with p-quinols is presented. This methodology utilizes readily available indoles, furans and thiophene for Michael addition to p-quinols and subsequent aromatization to access phenol-assimilated heterocycles which have powerful applications both in synthetic and medicinal chemistry.
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