Abstract
Organic Chemistry Chemists typically transform carbonyl compounds through polar two-electron reactions. It is also possible to pursue radical coupling strategies by adding just one electron to form a ketyl group. However, the strong reductant supplying that electron often limits the reaction's versatility. Wang et al. report a mild means of forming ketyls by first adding acetyl iodides across the C=O bond (see the Perspective by Blackburn and Roizen). A photoactivated manganese catalyst then temporarily pulls the iodine away, leaving a ketyl to couple with alkynes. The iodine then returns to one of the alkyne's carbons, stabilizing the product but remaining poised for further transformations. Science , this issue p. [225][1]; see also p. [157][2] [1]: /lookup/doi/10.1126/science.aau1777 [2]: /lookup/volpage/362/157?iss=6411
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