Abstract
AbstractA new method is described for the metal‐free oxidation of o‐vinyl diaryl ketones in the presence of molecular iodine or N‐iodosuccinimide to give o‐acetyl diaryl ketones. This transformation involves the initial formation of an iodohydrin, and the o‐carbonyl group of the iodohydrin participates in a subsequent rearrangement to give the o‐acetyl diaryl ketone. The presence and participation of ortho‐carbonyl group is necessary for successful conversion. The envisaged 1‐methyl‐4‐arylphthalazines were synthesized from these o‐acetyl diaryl ketones, and their antiproliferative activity on mammalian cell lines was studied.
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