Abstract
A general and efficient multi-component reaction has been established for the construction of 5-amino tetrazoles and guanidines under mild reaction conditions. All the substrates are readily carried out under optimized reaction conditions to provide their respective target products in good to excellent yields. The regioselectivity of the reaction is also explained in this manuscript. Further, this method is free, uses water as a green solvent, and is practical (at room temperature and under an open atmosphere). In addition, we could not identify any other products during the reaction procedure. Phenyltetrazoleamines are readily converted into their C-N cross-coupled products in good to high yield under mild reaction conditions.
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