Iodine-mediated sp³ C-H functionalization of methyl ketones: a one-pot synthesis of functionalized indolizines via the 1,3-dipolar cycloaddition reaction between pyridinium ylides and ynones.

Abstract

An efficient transition-metal-free approach toward C-H bond activation by using molecular [Formula: see text]-mediated [Formula: see text] C-H bond functionalization for the synthesis of indolizine derivatives via 1,3-dipolar cycloaddition reaction of nitrogen ylides with ynones is described.