Abstract
AbstractThis protocol describes an iodine/manganese catalytic system for dehydrogenative oxidative coupling reaction of indoles with thiols in anisole. Particularly, the dual roles of anisole have been first demonstrated as a solvent and as a promoter via the formation of an oxonium ion intermediate to accelerate the generation of products. A series of sulfenylindoles are readily constructed under aerobic mild reaction conditions. In addition, the achievement for preparing anticancer and anti‐AIDS drugs testifies the practicability of this approach. The mechanism studies disclose probable alternative pathways and a single‐electron transfer process are involved in this transformation.magnified image
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