Abstract
Cancer represents the second most important cause of death and morbidity in Europe, with more than 3.7 million new cases and 1.9 million deaths reported each year. Computed tomography plays a fundamental role in the management of oncology patients, and the superior diagnostic value that contrast-enhanced images offer is frequently critical. It is well recognized that iodinated contrast media have a cytotoxic effect, and this is felt to be one of the mechanisms responsible for contrast-induced nephrotoxicity. The study aims to analyze the correlation between administration of iodinated contrast substance (namely, Iohexol) and serum creatinine values 48 hours afterwards in patients with oncological conditions undergoing chemotherapy, which perform CT examinations (observational study). Keywords: CT, contrast media induced nephropathy, chemotherapy
Highlights
Cancer represents the second most important cause of death and morbidity in Europe, with more than 3.7 million new cases and 1.9 million deaths reported each year
The study was conducted over a period of 6 months beginning on 01.06.2018 and included patients admitted to the Oncology Department of the “Colţea” Clinical Hospital in Bucharest, who had an indication for a Computed tomography (CT) scan with administration of intravenous iodine contrast substance
The chemical formula of iohexol (Omnipaque®) is C19H26I3N3O9, as: 5-[N-(2,3-Dihydroxypropyl)acetamido]-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamide, and the molar mass of Iohexol is 821.138 g/mol g·mol−1. In this group of 59 patients with diagnosed neoplasia, all investigated with contrast enhanced computed tomography, the median age was 59.69 years, with a rage of 39-81 years, and a male: female rate of 1:1.26
Summary
The study was conducted over a period of 6 months beginning on 01.06.2018 and included patients admitted to the Oncology Department of the “Colţea” Clinical Hospital in Bucharest, who had an indication for a CT scan with administration of intravenous iodine contrast substance. The characteristics of the equipment, the contrast agent used and the technique of its administration were as follows:. -Iodinated water-soluble contrast substance, 350mg/mL, administered intravenously with the injector, with a flow rate of at least 2.5mL/s, with a delay of 25 seconds until the first postcontrast acquisition. According to the prospectus of the contrast substance, the active substance is Iohexol, having the content per milliliter of 755 mg equivalent to 350 mg of iodine. Iohexol is an X-ray contrast agent, water-soluble, tri-iodate, monomeric, nonionic. Iohexol, is sold under the trade name Omnipaque®, and its osmolarity and viscosity values are listed in tabel 1: Concentration
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