Abstract
BackgroundThe aim of this study was to investigate the correlation of the dual energy CT measured iodine concentration and total iodine content with blood measured thyroid parameters.MethodsForty-three patients with normal thyroid function at our hospital from August 2017 to October 2019 were included in this retrospective study. Dual energy CT was used to scan the neck of thyroid patients. The mean iodine concentration and thyroid tissue volume were measured to calculate the total iodine content of the thyroid. Relevant tests of triiodothyronine (FT3), total triiodothyronine (TT3), total thyroxine (TT4), free thyroxine (FT4), and thyroid hormone (TSH) were conducted. The correlation of the thyroid mean iodine concentration and total iodine content with blood-measured thyroid function was analysed.ResultThe total iodine content in the thyroid was positively correlated with FT3 but negatively correlated with TSH. The mean iodine concentration of the thyroid was positively correlated with both FT3 and TT3.ConclusionThe thyroid iodine content measured by dual energy CT can be used to determine the human iodine nutritional status and evaluate thyroid function, which will facilitate the diagnosis and treatment of thyroid diseases.
Highlights
The aim of this study was to investigate the correlation of the dual energy Computed tomography (CT) measured iodine concentration and total iodine content with blood measured thyroid parameters
The thyroid iodine content measured by dual energy CT can be used to determine the human iodine nutritional status and evaluate thyroid function, which will facilitate the diagnosis and treatment of thyroid diseases
We manually marked the Region of interest (ROI) on the Detection of thyroid function related indicators (Table 1) A total of 42 cases were detected for the five thyroid function indices, including Free triiodothyronine (FT3), Serum free thyroxine (FT4), Thyroid stimulating hormone (TSH), TT3 and TT4
Summary
The aim of this study was to investigate the correlation of the dual energy CT measured iodine concentration and total iodine content with blood measured thyroid parameters. Iodine entering the human body concentrates in the thyroid gland. Both iodine deficiency and iodine excess can cause changes to the morphology and function of the thyroid [1, 2]. The measurement of thyroid iodine is helpful to determine the human iodine nutritional status and has a certain value for the evaluation of thyroid function. Previous studies measuring the iodine concentration in phantom have shown that dual energy CT (DECT) is highly accurate in measuring the iodine concentration [3, 4]. Shao Weiguang [5] and others proved that gemstone energy spectrum CT imaging made
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