Abstract
P atients are frequently asked about iodine or seafood allergy before IV contrast material is administered because of a commonly held belief among radiologists and others in the medical community of a specific cross-reactivity between iodinated radiographic contrast material and other iodine-rich substances. “Iodine allergy” is often used as a collective term for adverse reactions to these agents. Patients commonly provide positive or ambiguous responses to such questions; such responses are likely to become more common with the increasing consumption of seafood and the increasing prevalence of allergies in the general population. Our purpose is to show that iodine does not confer a specific cross-reactivity between iodine-rich substances, that the cross-reactivity that does exist is nonspecific, and that the concept of iodine allergy is fallacious and may result in the inappropriate nonuse of IV contrast material in patients intolerant of antiseptics or seafood that contain iodine.
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