Abstract
The synthesis and spectral properties (MS, and NMR) of radioiodinated β-carbolines: 6-(I) and 8-(II) [131I]-iodo-1-methyl-7-methoxy-β-carboline([131I]-iodo-harmine), 6-(III) and 8-(IV) [131I]-iodo-1-methyl-β-carboline-7-ol([131I]-iodo-harmol), 8-[131I]-iodo-1-methyl-7-methoxy-3,4-dihydro-β-carboline(8-[131I]-iodo-harmaline) (V), 8-[131I]-iodo-3,4-dihydro-1-methyl-β-carboline-7-ol(8-[131I]-iodo-harmalol) (VI), 6-[131I]-iodo-1-methyl-β-carboline(6-[131I]-iodo-harmane) (VII) are described. These are compounds of biological importance and can be used for brain mapping with SPECT technology. Copyright © 1999 John Wiley & Sons, Ltd.
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