Abstract
Radioiodide was injected into newborn rats, their thyroids were digested and the digests fractionated by paper chromatography. Rats born to iodine—deficient dams were studied at various ages, 1–4 days, 14 days, 59 days and 94 days. After weaning, the dams and the young rats continued on a Remington low—iodine diet. Results were compared to controls of comparable age and fed commercial laboratory chow. Contrary to previous reports on adult rats fed the Remington low—iodine diet for three months and over, the young rat thyroid contained, at all ages up to 59 days, less labeled T3 than T4. The low percentage T3 in the thyroids of the youngest rats contrasted with the low—iodine content, increased 125I uptake, increased thyroid weight and a high ratio of labeled MIT to DIT. Compared to their normal controls, each age group of iodinedeficient young rats had a significantly lower percentage labeled thyroidal T3. It was concluded that newborn rats do not adapt to iodine deficiency as the adult. (Endocrinology92: 1376, 1973)
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