Abstract
I.v. administration of (−)- Δ 9-trans-tetrahydrocannabino ( Δ 9-THC) to chloralose-anesthetized cats produced a decrease in blood pressure and heart rate. Studies conducted to investigate the mechanism of these changes revealed that the hypotensive and bradycardic effects of Δ 9-THC (0.1 mg/kg, i.v.) could be significantly antagonized following intraventricular (i.v.t.) perfusion with α-adrenergic receptor blocking agent phentolamine, while a larger dose of Δ 9-THC (0.25 mg/kg, i.v.) still produced significant hypotension and bradycardia. I.v.t. perfusion of phentolamine (100 μg/min for 30 min) caused a fall in blood pressure and heart rate which were reversible and produced blockade of central α-adrenergic receptors. These results provide evidence for the involvement of central α-adrenergic receptors in the hypotensive and bradycardic actions of Δ 9-THC and indicate that other receptor mechanisms may also be involved in mediating these responses observed following administration of Δ 9-THC.
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