Abstract
SOX2 is a key transcription factor in embryonic development representing a universal marker of pluripotent stem cells. Based on the functional redundancy and overlapping expression patterns of SOXB1 subgroup members during development, the goal of this study has been to analyze if some aspects of regulation of expression are preserved between human SOX2 and SOX3 genes. Thus, we have tested several transcription factors previously demonstrated to play roles in controlling SOX3 gene activity for potential participation in the regulation of SOX2 gene expression in NT2/D1 cells. Here we report on the activation of SOX2 expression by ubiquitous transcription factors (NF-Y, Sp1 and MAZ), TALE family members (Pbx1 and Meis1), as well as liganded RXR?. Elucidating components involved in the regulation of SOX gene expression represent a valuable contribution in unraveling the regulatory networks operating in pluripotent embryonic cells.
Highlights
The SOX gene family encodes a highly conserved group of transcription factors that control cell fate and differentiation in numerous key developmental and physiological processes
Based on the functional redundancy and overlapping expression patterns of SOXB1 members during development, the goal of the present study has been to analyze whether some aspects of regulation of expression are preserved between human SOX2 and SOX3 genes
The study presented here was undertaken in order to examine the effect of selected transcription factors, which we have previously demonstrated to play roles in controlling SOX3 gene activity, for their potential participation in the regulation of SOX2 expression in a native context
Summary
KRSTIĆ, MARIJA MOJSIN, DANIJELA DRAKULIĆ and MILENA STEVANOVIĆ. Abstract - SOX2 is a key transcription factor in embryonic development representing a universal marker of pluripotent stem cells. We have tested several transcription factors previously demonstrated to play roles in controlling SOX3 gene activity for potential participation in the regulation of SOX2 gene expression in NT2/D1 cells. We report on the activation of SOX2 expression by ubiquitous transcription factors (NF-Y, Sp1 and MAZ), TALE family members (Pbx and Meis1), as well as liganded RXRα. Elucidating components involved in the regulation of SOX gene expression represent a valuable contribution in unraveling the regulatory networks operating in pluripotent embryonic cells
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