INVOLVEMENT OF THE PROSTATE BY CHRONIC LYMPHOCYTIC LYMPHOMA, CLINICAL AND PATHOLOGICAL CHARACTERIZATION

Abstract

Introduction: Few reports have described the involvement of the prostate by hematolymphoid infiltrate; the usual presentation is that of benign prostatic hyperplasia, because of the rarity of the condition; there is no specific diagnostic or treatment paradigm. We set out to study the clinicopathological features for this occurrence. Material and Method: This is a retrospective review to describe the clinical and pathological characters of secondary involvement of the prostate by chronic lymphocytic leukemia/lymphoma. Cohort included male patients above the age of 40 years who were diagnosed to have CLL with secondary infiltration of the prostate gland.Results: Among 1512 pathologies reviewed; nine patients were found to have involvement of the prostate gland by CLL. The discovery of the prostate involvement was proved either by pathology examination of prostate chips obtained by Tran Urethral Resection of the prostate or Tranrectal Ultrasound guided prostate biopsy. The average age 57.6 years, prostate specific antigen 2.52 ng/ml AUA-score 23/35, abnormal Digital Rectal Examination 2/9, prostate volume 64 gm. Cohort was contrasted with our institutional prostate diseases database.Conclusion: Prostate gland might be an overlooked site of Chronic Lymphocytic leukemia infiltrate; patients usually present with severe obstructive symptoms and/or abnormal PSA/Digital Rectal Examination. Urologists and pathologists and should be oriented to the mode of presentation, diagnostic and treatment approaches of this population of patients.