Abstract
Abstract The aim of the present study was to investigate the involvement of the monoaminergic system in antidepressant-like effects of a characterized ethanolic extract of Mentha piperita (MP) in the forced swimming test (FST) in male mice. The animals were intraperitoneally (i.p.) treated with the MP extract (50–400 mg/kg) one hour before FST. To examine the involvement of the monoaminergic system in the antidepressant-like effect of MP, receptor antagonists were administrated fifteen minutes prior to the MP extract treatment (400 mg/kg, i.p) to mice and after one hour the FST was carried out. The MP extract (200 and 400 mg/kg, i.p.) showed a significant antidepressant-like effect (P
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