Abstract
Four superoxide dismutase active copper chelates, Cu(acetylsalicylate) 2, Cu(salicylate) 2, Cu(lysine) 2 and Cu(tyrosine) 2, proved to be inhibitors of prolyl and lysyl hydroxylase. The kinetics of the inhibition are consistent with the proposal that these compounds dismutated • O 2 staggered− at the active site of the enzymes. The data strongly suggest that • O 2 staggered− is the active form of O 2 in the prolyl and lysyl hydroxylase reactions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.