Abstract
we set up a blank control group with WKY rats (n=6 in each group). All animals were treated for 4 weeks. The expression of mRNA and the protein level of TRPC3 and TPRC6 in aorta were determined by RTPCR, immunohistochemistry and Western blot analysis respectively. Result: Compared with black control group, the systolic blood pressure was increased in experimental control group, Pb0.05 before treatment. With 4 weeks treatment, the blood pressure in the three medication groups was decreased than it was before the medication (Pb0.05), the expression of mRNA and the protein level of TRPC3 were also decreased (Pb0.05). The expression of mRNA and the protein level of TRPC3 and TRPC6 had no obvious changes among the three medication groups. Conclusion: Ramipril, valsartan and amlodipine could reduce the blood pressure and meanwhile, reduce the expression of mRNA and the protein level of TRPC3 in SHR, which implied that TRPC3 might be involved in the regulation of blood pressure in SHR.
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