Involvement of nuclear factor kappa-B in development of neonatal onset multisystem inflammatory disease

Abstract

The present study investigated the relationship between nuclear factor-κB1 gene (NFkB1) and neonatal onset multisystem inflammatory disease (NOMID) among Chinese neonates. We therefore aimed to investigate whether nuclear factor kappa-B involved in development of NOMID among Chinese neonates. Patients with confirm diagnosis of NOMID or healthy neonates was enrolled at Maternal and child health hospital of Hubei province, China. Involvement of poly (ADP-ribose) polymerase-1 (PP-1) and nuclear factor-κB1 was assessed using PCR techniques with the help of DNA sample. A total of 220 Chinese neonates with NOMID, and 220 healthy neonates were completed study. We note that the involvement of del/ins of NFkB1 gene in development of NOMID among Chinese neonates. GG and G SNPs of PP-1 were found responsible for developing NOMID and the individuals with GA SNPs protect responsible for protecting from NOMID. Thus, nuclear factor-κB1 and PP-1 involved in cause of NOMID, and considering as risk of developing is approx. 2 times higher compared to healthy subjects. Our study result shown that polymorphism of nuclear factor-κB1 and PP-1 is involved in development of NOMID in China. Our study suggested that NFkB1 and PP-1 is a possible target for treatment of NOMID; the treatment targeting nuclear NFkB1 and PP-1 is useful for effective patient care. Our study results encourage conducting large trial evaluating role of NFkB1 and PP-1 polymorphism in NOMID.