Abstract
Aim: To address whether KGF (Keratinocyte Growth Factor) and KGFR (keratinocyte Growth Factor Receptor) expression is involved in the wound healing process of tracheal cartilage in rat longitudinal tracheotomy model. And to expose the new strategy to control the process utilizing KGF and its related compounds.Method: In this study, we incised rat trachea longitudinally for three cartilage lings, and harvested trachea from rat on 0, 1, 3, 5, 7 days after operation. We made horizontal section and observe them with immunohistochemistry.Result: The cartilage defect was filled with chondrocytes originated from the perichondrium. KGF expression was observed in chondrocytes, perichondrium and fibroblasts in injured area. The expression of KGF was upregulated immediately after the operation, reaching a peak at 3–5 days.Future approach: Further examination on temporal and spatial pattern of KGF and KGFR expression. Quantitative analysis of the expression of KGF and KGFR in relation to cell kinetics. Attempts to manipulate the kinetics of wound healing using KGF and its related compounds.
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