Abstract
Desferrioxamine (DES) protective effect against 1-methyl-4-phenylpyridinium (MPP +) toxicity was evaluated by microdialysis in the substantia nigra. DES (1 μM to 10 mM) co-perfused with MPP + (2.5 mM) on day 1, produced on day 2 a higher dopamine extracellular output after perfusion of MPP + than in control-MPP + perfusion experiments, in which no DES was administered on day 1. Both Ringer's perfusion alone (control-Ringer) and co-perfusion of DES (10 mM) with MPP + (2.5 mM) on day 1 produced on day 2 similar increases in dopamine extracellular output after a second MPP + perfusion. In the control-Ringer experiment, note that the MPP + on day 2 is the first MPP + perfusion. Perfusion of FeCl 3 (200 μM) along with MPP + (2.5 mM) and DES (100 μM) on day 1 completely abolished on day 2 the neuroprotective effect found with MPP + (2.5 mM) and DES (100 μM). The ability of DES to protect against MPP + toxicity may indicate a therapeutic strategy in the treatment of diseases when iron is implicated.
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