Abstract
The present study was performed to explore the role of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulate cortex (ACC) of normal rats and rats with mononeuropathy. Intra-ACC injection of galanin induced significant increases in hindpaw withdrawal latencies (HWLs) to thermal and mechanical stimulations in both normal rats and rats with mononeuropathy, the increased HWLs were attenuated significantly by intra-ACC injection of galanin receptor 2 antagonist M871, indicating an involvement of galanin receptor 2 in nociceptive modulation in ACC. Interestingly, the galanin-induced HWL was significant higher in rats with mononeuropathy than that in normal rats tested by Randall Selitto test. Furthermore, both the galanin mRNA expression and galanin content increased significantly in ACC in rats with mononeuropathy than that in normal rats. Moreover, both the mRNA levels of galanin receptor 2 and the content of galanin receptor 2 in ACC increased significantly in rats with mononeuropathy than that in normal rats. These results found that galanin induced antinociception in ACC in both normal rats and rats with mononeuropathy. And there may be plastic changes in the expression of galanin and galanin receptor 2 in rats with mononeuropathy, as well as in the galanin-induced antinociception.
Highlights
The present study was performed to explore the role of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulate cortex (ACC) of normal rats and rats with mononeuropathy
The results demonstrated that intra-ACC injection of galanin induced significant antinociceptive effects in normal rats
The present study demonstrated that administration of galanin into ACC induced significant increases in hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulations in normal rats and rats with mononeuropathy, indicate that galanin is involved in pain modulation in ACC in both normal rats and rats with mononeuropathy
Summary
The present study was performed to explore the role of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulate cortex (ACC) of normal rats and rats with mononeuropathy. Previous studies have demonstrated that galanin and galanin receptors play important roles in the transmission and/or modulation of nociception of the central nervous system, at spinal cord levels[7,9], as well as in the brain, such as hypothalamic arcuate nucleus, nucleus accumbens, periaqueductal grey, and the central nucleus of amygdala[10,11,12,13,14,15,16,17,18,19] Wang and her colleagues demonstrated that administration of galanin into periaqueductal grey induced significant antinociceptive effects in intact rats and rats with mononeuropathy[16,20]. The present study was performed to explore the role of galanin in nociceptive modulation in ACC of normal rats and rats with mononeuropathy, and further to explore the plastic changes in the expression of galanin and galanin receptor 2 in ACC in rats with mononeuropathy
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