Abstract
The effect of chloride and potassium channel blockers on the antinociception induced by GABAA receptor agonist muscimol was investigated using the paw pressure test. Muscimol (1, 2, 4, 8 ng/paw) elicited a peripheral antinociceptive effect that was antagonized by bicuculline (10, 20, 40, 80 ng/paw), suggesting a specific effect. The muscimol effect was reverted by the chloride channel coupled GABAA receptor blocker, picrotoxin (0.4, 0.6, 0.8, 2 μg/paw). Potassium channel blockers did not modify the peripheral antinociception induced by muscimol. This study provides evidence that the peripheral antinociceptive effect of muscimol results from the activation of GABAA receptor-associated chloride channels.
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