Involvement of executive control in neural capacity related to working memory in aging: an ERP P300 study.

Abstract

Executive control could be involved in neural capacity, which corresponds to the modulation of neural activity with increased task difficulty. Thus, by exploring the P300-an electrophysiological correlate of working memory-we examined the role played by executive control in both the age-related decline in working memory and neural capacity in aging. Event-related potentials (ERPs) were recorded while younger and older participants performed a Sternberg task with two set sizes (2 vs. 6 items), allowing us to calculate a neural capacity index. Participants also completed two control tasks (Stroop and 3-back tests), which were used to calculate a composite executive control index. Results indicated that working memory performance decreased with aging and difficulty. At the neural level, results indicated that the P300 amplitude varied with aging and also with task difficulty. In the low difficulty condition, frontal P300 amplitude was higher for older than for younger adults, whereas in the high difficulty condition, the amplitude of frontal and parietal P300 did not differ between both age groups. Results also suggest that task difficulty led to a decrease in parietal amplitude in both age groups and to an increase in frontal amplitude in younger but not older adults. Both executive control and frontal neural capacity mediated the age-related variance in working memory for older adults. Moreover, executive control mediated the age-related variance in the frontal neural capacity of older adults. Thus, the present study suggests a model for older adults in which executive control deficits with advancing age lead to less efficient frontal recruitment to cope with task difficulty (neural capacity), which in turn has a negative impact on working memory functioning.