Abstract
1. The possible involvement of eicosanoids, cyclic adenosine monophosphate (c-AMP), and inositol 1,4,5-trisphosphate (IP 3) in serotonin-(5-hydroxytryptamine-) induced secretion in rat ileum in vivo was studied. 2. Serotonin caused a significant increase in mean Ip 3 levels. Indomethacin reduced serotonin-induced secretion of water by 28%. Thus, Ip 3 and eicosanoids appear to be intracellular mediators of serotonin-induced secretion in rat ileum. 3. Serotonin, BRL 24924, and cisapride all inhibited theophylline-induced increases in c-AMP concentrations in rat ileal segments. Neither BRL 24924 nor cisapride caused any change in Ip 3 levels. 4. These data suggest that a 5-HT 2 receptor dependent on Ip 3 and eicosanoids is involved in mediating in serotonin-induced secretion in rat small intestine.
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