Involvement of D-Loop Mutations in the Occurrence of Ovarian Carcinoma

Oumar Mane ,Fatimata Mbaye ,Mbacké Sembène

doi:10.33696/cancerimmunol.2.015

Abstract

Highlights

Each cell in the body contains hundreds of mitochondria; each mitochondrion contains several DNA molecules, each carrying 37 genes that participate in the production of energy
In this study eleven (11) mutations (A66G, C186T, G309A, C388T, C418T, G421T, C422A, A425C, A425G, C431T and G499A) out of twenty-two (22) or 50% of the variants were identified in Mitomap as somatic mutations in ovarian cancer
Our study revealed a strong polymorphism in ovarian cancer in Senegalese women

Summary

Introduction

Each cell in the body contains hundreds of mitochondria; each mitochondrion contains several DNA molecules, each carrying 37 genes that participate in the production of energy. The mitochondria are organelles that function in a semi-autonomous manner, containing their own genome and are capable of replication and transcription. They are responsible for more than 90% of cellular ATP production through the process of oxidative phosphorylation [1]. Studies on mitochondria have shown that alterations in mtDNA are closely linked to hereditary diseases, ageing and cancer [2]. The involvement of mitochondria in apoptosis and probably in tumorigenesis has raised interest in the potential role of mtDNA mutations in the development of cancers [3]. Despite the small size of the mitochondrial genome, mtDNA mutations are an important cause of hereditary diseases. Considerable progress has been made in understanding mitochondrial genetics and identifying mutations in mtDNA acquired in cancers [5]

Objectives

Results

Discussion

Conclusion