Involvement of chromosomes 8, 9, 19 and 22 in PH1 positive and PH1 negative chronic myelocytic leukemia in the chronic or blastic stage.

Abstract

Abstract. Chromosome 9 had additional chromosomal material at the end of the long arm in 15 of 16 patients with Ph1 positive CML. The remaining patient had a normal chromosome 9but additional material on 19. The amount of additional material was approximately the same as that lacking on chromosome 22. Translocations between 9 and 22, and 19 and 22, respectively, are therefore suggested. One patient with Ph1 negative CML had no detectable additional chromosomal material on any chromosome including chromosome 9, which gives further support to the view that there is indeed a translocation in Ph1 positive patients. Extra chromosomes appeared in two of three Ph1 positive patients in the blastic stage. Both patients had extra number 8 chromosomes and double Ph1, and one patient had further extra chromosomes, i.e. 7, 11, 12, 16, 17 and 19.