Abstract
In this study, we investigated the relationship between catalase activity and H2O2-induced hormetic response in budding yeast S. cerevisiae. In general, our data suggest that: (i)hydrogen peroxide induces hormesis in a concentration- and time-dependent manner; and (ii) theeffect of hydrogen peroxide on yeast colony growth positively correlates with the activity ofcatalase that suggests the enzyme involvement in overall H2O2-induced stress response andhormetic response in yeast.
Highlights
Hormesis is a phenomenon of particular interest in biology, medicine, pharmacology and toxicology
An improvement of cellular and organismic functions by moderate stress is known as the phenomenon of hormesis, that may be graphically represented by the biphasic dose-response dependence, characterized by the stimulation in the low dose zone, followed by an inhibitory response at higher doses [10, 20]
The reproductive ability of yeast cells, that was determined as colony forming units (CFU), was assessed after the 60-min incubation period with different H2O2 concentrations
Summary
Hormesis is a phenomenon of particular interest in biology, medicine, pharmacology and toxicology. It has been observed in a variety of organisms: from bacteria to humans, responding to a wide range of chemical, physical, and biological stressors, including ionizing radiation, chemotherapeutic agents, metal ions, pesticides, antibiotics, ethanol, aldehydes, chloroform, prooxidants, hypergravity, and so forth [10, 20, 25, 26]. The specificity of stress response is determined by the nature of stressor, intensity/duration of its action, and physiological state of an organism. Hormesis may activate defense pathways ensure protection against higher doses of the same agent (“pre-adaptation”) as well as other specific stressors (“cross-protection”) [5, 28, 30]. Hormetic response suggests the existence of complex mechanisms, which sense and respond to different kinds of stress
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