Abstract
Diclofenac produced dose-dependent relaxation on vanadate-induced contraction of rat uterus incubated in calcium-free medium plus EDTA. This effect was antagonized by the inhibitors of cAMP-dependent protein kinases Rp-adenosine 3′,5′-monophosphothionate, triethylamine salt (1, 10 and 100 μM) and N-p-tosyl-L-phenylalanine-chloromethyl-ketone (1 and 10 μM). The inhibitor of phosphatases (okadaic acid, 0·1 and 0·3 μM) also reduced the effect of diclofenac. Our results suggest that the spasmolytic effect of diclofenac is mediated by cAMP.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
