Abstract
Shigella dysenteriaerepresent one of the growing list of antibiotic-resistant bacteria. Quinolones are widely employed to treat shigellosis. However, quinolone resistance has already been reported, necessitating an understanding of the mechanisms of development of resistance. We demonstrate that high-level fluoroquinolone resistance ofS. dysenteriaeexposed to these antibiotics may occur in the absence ofgyrAmutations and involve a proton motive force(pmf)-dependent efflux system.
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