Abstract
It was shown that at least four regions in the 2.2 kb upstream DNA of the sst1 gene are important for the cell type-specific promoter activity in GH3 and RIN cells. Moreover, the 48 bp region located between -165 to -117 harbors positive regulatory elements that are active in RIN and GH3 cells. This region is recognized by the pituitary-specific transcription factor Pit-1. It is therefore concluded that Pit-1 represents a major regulator of GH secretion at the genetic level by regulating transcriptional activity not only of the GH gene itself but also of the genes for the receptors that mediate stimulation and inhibition of GH secretion.
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