Abstract
The present study examined the hypothesis that μ-opioid receptors contribute to a behavioral stimulation produced by stimulation of dopamine receptors by comparing responses in μ-opioid receptor knockout and wild type mice. Apomorphine-induced climbing behavior was augmented by 65%, in wild type mice, but not in μ-knockout, following subcutaneous administration of morphine (15 mg/kg). Moreover, pretreatment with either naloxone (an opioid receptor antagonist) or haloperidol (a mixed D 1/D 2 receptor antagonist) eliminated the enhancement by morphine of climbing behavior in wild type mice. These results indicate that expression of μ-opioid receptors plays an important role in the enhancement of climbing behavior induced by the dopamine receptor agonist, apomorphine. Furthermore, this augmentation is mediated by interaction between dopamine and μ-opioid receptors.
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