Abstract
Hemocompatibility is an essential prerequisite for the application of materials in the field of biomedicine and biosensing. In addition, mixed ionic and electronic conductivity of conducting polymers is an advantageous property for these applications. Heparin-like materials containing sulfate, sulfamic, and carboxylic groups may have an anticoagulation effect. Therefore, sodium dodecylbenzenesulfonate, 2-aminoethane-1-sulfonic acid and N-(2-acetamido)-2-aminoethanesulfonic acid were used for modification of the representative of conducting polymers, polyaniline, and the resulting products were studied in the context of interactions with human blood. The anticoagulation activity was then correlated to surface energy and conductivity of the materials. Results show that anticoagulation activity is highly affected by the presence of suitable functional groups originating from the used heparin-like substances, and by the properties of polyaniline polymer itself.
Highlights
The hemocompatibility of any material is a crucial factor in its application in biomedicine, regenerative medicine, or biosensors
Conducting polymers have a huge potential for the mentioned applications as they show mixed ionic and electronic conductivity, which is preferred for electrically active biointerfaces
We focused on one of the important aspects of blood coagulation, namely on the detection of coagulation induced by the surface properties of modified PANI films
Summary
The hemocompatibility of any material is a crucial factor in its application in biomedicine, regenerative medicine, or biosensors. The phenomenon of hemocompatibility is very complex and comprises various processes of which blood coagulation remains at the center of attention when tissue engineering and biosensing applications are considered. In some special applications (e.g., biosensing or tissue engineering of electrosensitive tissues) the conductivity of materials can be an advantage. Common conducting materials (such as metals or metal oxides) can induce an undesired reaction on contact with tissues (e.g., because of their different elasticity compared to native tissue). Conducting polymers have a huge potential for the mentioned applications as they show mixed ionic and electronic conductivity, which is preferred for electrically active biointerfaces
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