Abstract
The assembly of fibrinogen to a fibrin network has great implications not only for physiological processes, like hemostasis and wound healing, but also for the inspiration of new biomaterials. In this review, we first introduce the structural basis of the fibrinogen monomer and the multi-step process of the assembly of the fibrin network triggered by thrombin. Then, we discuss the structure–property relationship of fibrin mechanics at different scales based on different characterization methods. Moreover, we focus on a factor that has received increasing attention, surface properties, and review the current findings about the influence of surface charge, wettability, and surface morphology on network formation. Further studies are necessary to decipher the structural origin and in-vivo implications of fibrin mechanics with more advanced characterization techniques. The structure, mechanics, and fibrinolysis of fibrin clots on material surfaces also have great potential for future research.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Current Opinion in Colloid & Interface Science
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.