Abstract
RF magnetron sputtering was successfully applied in this study to deposit ZnO nanoparticles on hydroxyapatite tablets. Field emission scanning electron microscopy (FE-SEM) images showed the growth of ZnO nanoparticles with a grain size of ∼ 20 nm. Sedimentation occurred on the surface of samples after their immersion in simulated body fluid. Energy dispersive spectroscopy (EDS) analysis, confirmed the presence of Ca, P, Zn, and O elements, while MAP analysis indicated the uniform distribution of hydroxyapatite and ZnO elements. Atomic force microscopy (AFM) revealed lower surface roughness in the coated samples as compared to their uncoated counterparts. The root means square of roughness decreased with the ZnO coating. X-ray diffraction (XRD) results suggest the presence of the ZnO and hydroxyapatite phases. Antibacterial assay of ZnO-coated and uncoated tablets indicated the higher bioactivity of ZnO-coated tablets against E. coli. The atomic absorption spectrophotometry (AAS) and flame photometer results showed the release of Zn2+ and Ca2+ ions from the samples, respectively. During 14 days of immersion in simulated body fluid (SBF), Due to corrosion and destruction of the surface of the samples the Ca2+ concentration of ZnO-coated and uncoated samples, as well as the concentration of Zn2+ ions of ZnO-coated samples exhibited an increase.
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