Invitro Anticancer Activity of Seagrass Cymodocea Serrulata Against Different Cell Lines

Abstract

Seagrasses have a long history of being used for a variety of remedial purposes, such as the treatment of fever, skindiseases, muscle pains, wounds, and stomach problems. Cancer is a debilitating disease resulting from uncontrolled proliferation.One major treatment strategy for cancer is the application of chemotherapeutic drugs which kill cancer cells. In this study, theanticancer potentials of Cymodocea serrulata seagrass were investigated against the MCF7 cell line (Human breast adenocarcinomacell line) and SHP-77 (human lung adenocarcinoma epithelial cell line). Cytotoxicity of seagrass extract was determined by MTTassay. The results showed that the ethanolic extract of Cymodocea serrulata has moderate anticancer activity, and the IC50 valuewas recorded. The most potent anticancer activity was observed with the ethanolic extract of C. serrulate with IC50 values of 52.5μg/ml and 51.7μg/ml on MCF7 and SHP-77 cells respectively. The ethanolic extract would be studied further to isolate andcharacterize active components for lead optimization studies.