(Invited) Study of Electrochemiluminescence Nanohybrid and Their Application in Biomarker Detection of Myocardial Infarction

Abstract

Electrochemiluminescence (ECL) as an analytical technique has attracted increasing attention in clinical diagnosis and environmental assays due to the controllability in temporal, space, and light emitting intensity, simple operation, cost-effectiveness, high sensitivity, and low background signal. Compared to other methods for biomarker detection of Myocardial Infarction, ECL shows high sensitivity and a wide detecting range.The common biomarkers for myocardial infarction include troponin, creatine kinase, myoglobin copeptin, and miRNA. Among those biomarkers, cTnI not only has excellent cardiac specificity but also can provide a long detecting window for cardiac injury, which has been acknowledged as the principal biomarker for AMI.We have developed ECL nanohybrid materials and detection methods for the applications in biomarker detection of myocardial infarction, which include Ru-MOF nanosheet, Ru linking BPEI-coated carbon dots, dual-wavelength ratiometric ECL biosensor, ratiometric ECL–electrochemical(EC) hybrid biosensor, wavelength-resolved ECL resonance energy transfer (ECL-RET) ratiometric immunosensor and so on. These ECL biosensors immunosensors exhibit excellent sensitivity, specificity, stability, and reproducibility. Therefore, they have great application prospects for biomarker detection in clinical diagnosis.ACKNOWLEDGMENTSThis work was supported by the National Key Research and Development Program of China (2016YFA0201301), the National Natural Science Foundation of China (No. 21435005 and 21627808), the Key Research Program of Frontier Sciences, CAS (no. QYZDY-SSW-SLH019).