Abstract
In this work, we will present single wall carbon nanotube optical reporters that can measure spatially and temporally resolved dynamic behavior of neuromodulatory molecules on scales that elude conventional methods of inquiry. We will present work on the performance of such sensors on phenolic and catecholinergic neuromodulators, and introduce new concepts for tuning their performance and selectivity. We will additionally present new approaches for deploying such sensors in biological preparations of varying complexity that permit application of the sensors in ways that improve their overall performance in tissue.
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