(Invited) Reduced Graphene Oxide Complexed to MnO2 Nanoparticles as Efficient Platform for Photothermal and Chemodynamic Combined Therapy

Abstract

The intracellular cascade reactions triggered by nanomateraials are emerging as promising strategies to treat cancer more efficiently, by exploting the specific tumour microenvironment [1]. One of the mechanisms of cell ablation is based on depletion of glutathione (GSH) and generation of reactive oxygen species (ROS). We recently exploited reduced graphene oxide (rGO), one of the most popular form of graphene, in combination with manganese dioxide nanoparticles (MnO2 NPs) to design a multifunctional nanoplatform (rGO@MnO2) for efficient photothermal/chemodynamic combined therapies. Manganese-based NPs were bound onto the surface of rGO nanosheets (rGO NSs). These NPs are able to oxidize intracellular GSH, generating Mn2+ ions that convert H2O2 into hydroxyl radicals by Fenton reaction. In addition, rGO NSs mediated photothermal therapy (PTT) enhance the mortality of cancer cells. The high temperature caused by photothermal conversion increases the Fenton reaction rate, which enhances the efficiency of MnO2 NPs mediated chemodynamic therapy (CDT). Such type of hybrid materials has great potential in cancer therapy by exploiting the synergistic effect of PTT and CDT.[1] Ma, B.; Guo, S.; Nishina, Y.; Bianco, A. Reaction between Graphene Oxide and Intracellular Glutathione Affects Cell Viability and Proliferation. ACS Appl. Mater. Interfaces 2021, 13, 3528-3535. DOI:10.1021/acsami.0c17523[2] Ma, B.; Nishina, Y.; Bianco, A. A glutathione responsive nanoplatform made of reduced graphene oxide and MnO2 nanoparticles for photothermal and chemodynamic combined therapy. Carbon 2021, 178, 783-791. DOI:10.1016/j.carbon.2021.03.065