(Invited) Recent Progress in Functional Nanomaterials for Biosensing and Theranostics

Abstract

In this talk, I will present an overview of our pioneering research in functional nanomaterials for biosensing and theranostics. Our work primarily focuses on novel materials such as protein cages, peptoids, single-atom nanozymes, and nanoflowers, and their applications in the field of biosensing and theranostics.Building on my extensive background in developing materials and systems for biosensors, including immunosensors and microfluidic devices, we have explored the development of various smartphone-based biosensors. These biosensors are primarily based on DNA assays and immunoassays for point-of-care diagnostics, significantly enhancing the detection of disease biomarkers. Our research utilizes nanomaterials loaded with optical or electroactive signal molecules as amplification tags, dramatically improving the sensitivity in detecting disease biomarkers and food pathogens.An exciting frontier in our research is the application of nano-peptoids in cell imaging, single-particle tracking, and cancer theranostics. The unique properties of nano-peptoids, including their biocompatibility and the ability for precise control over interactions, have opened new avenues in biomedicine and healthcare. These advancements hold promise for groundbreaking applications, particularly in enhancing the efficacy and precision of cancer diagnostics and treatment.Moreover, the integration of 3D printing technology has enabled us to fabricate compact and efficient devices, a testament to our commitment to innovation in biosensor technology.Throughout this talk, we will delve into the intricate details of these innovations, discussing their implications for the future of biosensing and theranostics.